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How do new types of corona virus protect themselves from the immune response?

There are mutations in the rapidly spreading types of the coronavirus, which help the virus to some extent survive the immune response caused by the disease or vaccine.

This was revealed in a medical study conducted in the United States. 

coronavirus


Experts from Germany and the Netherlands also worked on the Scrappers Research Institute in the United States, which revealed important details about mutations.

The research examined how structural biology techniques were used to inactivate virus-defying antibodies against the original and new types of the virus. The extent to which their actions affect species discovered in the UK, South Africa, India, and Brazil.

Types of Corona's concern include Type B117 discovered in the UK, Type B1351 discovered in South Africa, Type P1 discovered in Brazil, and Type B1617 discovered in India.

These types are considered more contagious than the original type of the virus that spreads in Wuhan, and recent research reports have found that antibodies to these types are less effective after being infected with the original virus or after vaccination.

Because it is thought that these new types can make people sick despite vaccinations in some cases, experts have tried to figure out how these types can avoid an immune response.

For the study, experts focused on 417N, E484K, and N501Y of the three mutations in the spike protein of the coronavirus.

Together or separately, these mutations have been discovered in most new types of the corona, all at the site of attachment to the virus's receptor.

The researchers examined the antibodies and found that most of these antibodies significantly reduced the ability of the virus to bind and inactivate.

Using structural imaging techniques, the researchers mapped out different parts of the virus and examined how mutations affect the areas where antibodies bind and inactivate the virus.

The results suggest that antibodies are very effective against the original type of the virus, but certain types can prevent it, so vaccines will need to be updated gradually.

Similarly, the study found that 3 mutations did not change the location of the receptor binding.

The results of the study were published in the medical journal Science.

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